trans-Dichlorodiamineplatinum(II)

Modify Date: 2024-01-08 23:24:39

trans-Dichlorodiamineplatinum(II) Structure
trans-Dichlorodiamineplatinum(II) structure
Common Name trans-Dichlorodiamineplatinum(II)
CAS Number 14913-33-8 Molecular Weight 300.051
Density 3.746 g/cm3 Boiling Point N/A
Molecular Formula H6Cl2N2Pt Melting Point 340ºC (dec.)
MSDS Chinese USA Flash Point N/A
Symbol GHS05 GHS08
GHS05, GHS08
Signal Word Danger

 Names

Name transplatin
Synonym More Synonyms

 Chemical & Physical Properties

Density 3.746 g/cm3
Melting Point 340ºC (dec.)
Molecular Formula H6Cl2N2Pt
Molecular Weight 300.051
Exact Mass 298.955597
PSA 6.48000
LogP 2.02430
Index of Refraction 1.706
Water Solubility Soluble in dimethylsulfoxide and dimethylformamide. Slightly soluble in water.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TP2455000
CHEMICAL NAME :
Platinum (II), diamminedichloro-, trans-
CAS REGISTRY NUMBER :
14913-33-8
LAST UPDATED :
199709
DATA ITEMS CITED :
28
MOLECULAR FORMULA :
Cl2-H6-N2-Pt
MOLECULAR WEIGHT :
300.07
WISWESSER LINE NOTATION :
.PT..ZH2.G2 -T

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
27 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
32408 ug/kg/10W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors

MUTATION DATA

TYPE OF TEST :
DNA adduct
TEST SYSTEM :
Mammal - species unspecified Lymphocyte
DOSE/DURATION :
50 umol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 10,27,1975

 Safety Information

Symbol GHS05 GHS08
GHS05, GHS08
Signal Word Danger
Hazard Statements H317-H318-H334
Precautionary Statements P261-P280-P284-P304 + P340-P305 + P351 + P338 + P310
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes T:Toxic;
Risk Phrases R23/24/25;R40;R42/43;R68
Safety Phrases S24-S36/37
RIDADR UN 3288
WGK Germany 3
RTECS TP2455000
Packaging Group II
Hazard Class 6.1(a)

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 Synonyms

trans--diamminedichloroplatinum(II)
EINECS 238-980-9
trans-diamminodichloroplatinum(II)
trans-diaminedichloroplatinum(II)
UNII:Q20Q21Q62J
Dichloroplatinum diammoniate
trans-Platinum diammine dichloride
MFCD00011623
CIS-PLATIN
transplatin
trans-dichlorodiammineplatinum(II)
trans-dichlorodiamine platinum(II)
trans-Dichlorodiamineplatinum(II)
Cisplatin impurity A
trans-Diamminedichloroplatinum(II) (trans-Dichlorodiammineplatinum(II)
cis-Diamminedichlorplatine