trans-Dichlorodiamineplatinum(II)

Names

[ Name ]:
trans-Dichlorodiamineplatinum(II)

[Synonym ]:
trans--diamminedichloroplatinum(II)
EINECS 238-980-9
trans-diamminodichloroplatinum(II)
trans-diaminedichloroplatinum(II)
UNII:Q20Q21Q62J
Dichloroplatinum diammoniate
trans-Platinum diammine dichloride
MFCD00011623
CIS-PLATIN
transplatin
trans-dichlorodiammineplatinum(II)
trans-dichlorodiamine platinum(II)
trans-Dichlorodiamineplatinum(II)
Cisplatin impurity A
trans-Diamminedichloroplatinum(II) (trans-Dichlorodiammineplatinum(II)
cis-Diamminedichlorplatine

Chemical & Physical Properties

[ Density]:
3.746 g/cm3

[ Melting Point ]:
340ºC (dec.)

[ Molecular Formula ]:
H₆Cl₂N₂Pt

[ Molecular Weight ]:
300.051

[ Exact Mass ]:
298.955597

[ PSA ]:
6.48000

[ LogP ]:
2.02430

[ Index of Refraction ]:
1.706

[ Water Solubility ]:
Soluble in dimethylsulfoxide and dimethylformamide. Slightly soluble in water.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TP2455000

CHEMICAL NAME :: Platinum (II), diamminedichloro-, trans-

CAS REGISTRY NUMBER :: 14913-33-8

LAST UPDATED :: 199709

DATA ITEMS CITED :: 28

MOLECULAR FORMULA :: Cl2-H6-N2-Pt

MOLECULAR WEIGHT :: 300.07

WISWESSER LINE NOTATION :: .PT..ZH2.G2 -T

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 27 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 32408 ug/kg/10W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 50 umol/L

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 10,27,1975

Safety Information

[ Symbol ]:

GHS05, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H317-H318-H334

[ Precautionary Statements ]:
P261-P280-P284-P304 + P340-P305 + P351 + P338 + P310

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R23/24/25;R40;R42/43;R68

[ Safety Phrases ]:
S24-S36/37

[ RIDADR ]:
UN 3288

[ WGK Germany ]:
3

[ RTECS ]:
TP2455000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

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