naftalofos

Modify Date: 2025-09-15 23:36:49

naftalofos structure	Common Name	naftalofos
	CAS Number	1491-41-4	Molecular Weight	349.275
	Density	1.4±0.1 g/cm3	Boiling Point	487.3±28.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₆NO₆P	Melting Point	115-116ºC
	MSDS	Chinese USA	Flash Point	248.5±24.0 °C
	Symbol	GHS06	Signal Word	Danger

Use of naftalofos

Naftalofos is an insecticide and an anthelmintic. Naftalofos represents an effective therapeutic alternative for incorporation into worm control programmes.

Name	naftalofos
Synonym	More Synonyms

Density	1.4±0.1 g/cm3
Boiling Point	487.3±28.0 °C at 760 mmHg
Melting Point	115-116ºC
Molecular Formula	C₁₆H₁₆NO₆P
Molecular Weight	349.275
Flash Point	248.5±24.0 °C
Exact Mass	349.071533
PSA	93.64000
LogP	2.01
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.612

naftalofos MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QK5775000

CHEMICAL NAME :: Naphthalimide, N-hydroxy-, diethyl phosphate

CAS REGISTRY NUMBER :: 1491-41-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C16-H16-N-O6-P

MOLECULAR WEIGHT :: 349.30

WISWESSER LINE NOTATION :: T666 1A M CVNVJ DOPO&O2&O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued. Volume(issue)/page/year: 9,119,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740) Volume(issue)/page/year: 78-1,45,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARSIM* Agricultural Research Service, USDA Information Memorandum. (Beltsville, MD 20705) Volume(issue)/page/year: 20,3,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 43300 ug/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 11,49,1967

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 1960 mg/kg/2W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 11,49,1967 *** REVIEWS *** TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 46,1,1973

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H310
Precautionary Statements	P280-P301 + P310-P302 + P350-P310
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;
Risk Phrases	R24/25
Safety Phrases	36/37-45
RIDADR	UN 2783
RTECS	QK5775000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Phenobarbital induction and chemical synergism demonstrate the role of UDP-glucuronosyltransferases in detoxification of naphthalophos by Haemonchus contortus larvae.

Antimicrob. Agents Chemother. 58(12) , 7475-83, (2014)

We used an enzyme induction approach to study the role of detoxification enzymes in the interaction of the anthelmintic compound naphthalophos with Haemonchus contortus larvae. Larvae were treated wit...

The efficacy of trichlorphon and naphthalophos against multiple anthelmintic-resistant nematodes of naturally infected sheep in Argentina.

Parasitol. Res. 109 Suppl 1 , S139-48, (2011)

An anthelmintic efficacy trial was conducted in sheep harbouring anthelmintic-resistant worms in Argentina. Seventy lambs were selected from a flock that had been grazed on pastures infected with tric...

Pharmacology of anthelmintic resistance.

Parasitology 113 Suppl , S201-16, (1996)

Anthelmintic resistance has compromised the control of nematode parasites in several animal-based industries. Studies of resistance have not only improved our understanding of this phenomenon but also...

1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-[(diethoxyphosphinyl)oxy]-

O,O-Diethyl O-Naphthaloximide Phosphate

1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl diethyl phosphate

Naftalofosum

diethyl naphthalimidooxyphosphonate

Phtalophos

Rametin

EINECS 216-078-6

O,O-Diethyl N-hydroxynaphthalimide phosphate,Naphthalophos

Bayer S940

(1,3-dioxobenzo[de]isoquinolin-2-yl) diethyl phosphate

2-[(Diethoxyphosphoryl)oxy]-1H-benzo[de]isoquinoline-1,3(2H)-dione

phthalophos

Maretin

2-[(Diethoxyphosphinyl)oxy]-1H-benz[de]isoquinoline-1,3(2H)-dione

naftalofosum [INN_la]

Phosphorsaeure-(1,3-dioxo-2,3-dihydro-1H-benz[d,e]isochinolyl-(2)-ester)-diethylester

naftalofos

naphthalophos

Bayer 9002

Rawetin

MFCD00864515

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