doripenem

Modify Date: 2024-01-02 22:34:16

doripenem structure	Common Name	doripenem
	CAS Number	148016-81-3	Molecular Weight	420.504
	Density	1.6±0.1 g/cm3	Boiling Point	694.8±65.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₂₄N₄O₆S₂	Melting Point	>186ºC dec.
	MSDS	N/A	Flash Point	374.0±34.3 °C

Use of doripenem

Doripenem is a new member of the carbapenem class of beta-lactam antibiotics with broad-spectrum coverage of Gram-positive, Gram-negative and anaerobic pathogens.Target: AntibacterialDoripenem is an ultra-broad-spectrum injectable antibiotic. It is a beta-lactam and belongs to the subgroup of carbapenems. It was launched by Shionogi Co. of Japan under the brand name Finibax in 2005 and is being marketed outside Japan by Johnson & Johnson. It is particularly active against Pseudomonas aeruginosa. It is recommended that those allergic to doripenem or to any type of beta-lactam antibiotics such as cephalosporin or other Carbapenems not receive doripenem.Doripenem appears as crystalline powder anywhere from a white to somewhat yellowish colour.Doripenem is moderately soluble in water, slightly soluble in methanol, and virtually insoluble in ethanol. Doripenem is also solution in N,N-dimethylformamide. Doripenem's chemical configuration has 6 asymmetrical carbon atoms (6 stereocentres) and is most commonly supplied as one pure isomer. In terms of doripenem for injection, the crystallized powered drug can form a monohydrate when mixed with water. However, Doripenem has not been proven to possess polymorphism.

Name	Doripenem
Synonym	More Synonyms

Description	Doripenem is a new member of the carbapenem class of beta-lactam antibiotics with broad-spectrum coverage of Gram-positive, Gram-negative and anaerobic pathogens.Target: AntibacterialDoripenem is an ultra-broad-spectrum injectable antibiotic. It is a beta-lactam and belongs to the subgroup of carbapenems. It was launched by Shionogi Co. of Japan under the brand name Finibax in 2005 and is being marketed outside Japan by Johnson & Johnson. It is particularly active against Pseudomonas aeruginosa. It is recommended that those allergic to doripenem or to any type of beta-lactam antibiotics such as cephalosporin or other Carbapenems not receive doripenem.Doripenem appears as crystalline powder anywhere from a white to somewhat yellowish colour.Doripenem is moderately soluble in water, slightly soluble in methanol, and virtually insoluble in ethanol. Doripenem is also solution in N,N-dimethylformamide. Doripenem's chemical configuration has 6 asymmetrical carbon atoms (6 stereocentres) and is most commonly supplied as one pure isomer. In terms of doripenem for injection, the crystallized powered drug can form a monohydrate when mixed with water. However, Doripenem has not been proven to possess polymorphism.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
References	[1]. Anderson DL. Doripenem. Drugs Today (Barc). 2006 Jun;42(6):399-404. [2]. Jones RN, et al. Doripenem (S-4661), a novel carbapenem: comparative activity against contemporary pathogens including bactericidal action and preliminary in vitro methods evaluations. J Antimicrob Chemother. 2004 Jul;54(1):144-54. Epub 2004 Jun 9.

Description

Related Catalog

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

References

[1]. Anderson DL. Doripenem. Drugs Today (Barc). 2006 Jun;42(6):399-404.

[2]. Jones RN, et al. Doripenem (S-4661), a novel carbapenem: comparative activity against contemporary pathogens including bactericidal action and preliminary in vitro methods evaluations. J Antimicrob Chemother. 2004 Jul;54(1):144-54. Epub 2004 Jun 9.

Density	1.6±0.1 g/cm3
Boiling Point	694.8±65.0 °C at 760 mmHg
Melting Point	>186ºC dec.
Molecular Formula	C₁₅H₂₄N₄O₆S₂
Molecular Weight	420.504
Flash Point	374.0±34.3 °C
Exact Mass	420.113739
PSA	195.74000
LogP	-3.65
Vapour Pressure	0.0±4.9 mmHg at 25°C
Index of Refraction	1.681
Storage condition	-20°C Freezer

Hazard Codes	N

Precursor 7
CAS#:491878-07-0 Doripenem conde... CAS#:90822-24-5 (F-9 (M-6)) CAS#:104873-15-6 4-nitrobenzyl (... CAS#:51-35-4 L-Hydroxyproline
CAS#:13726-69-7 Boc-Hyp-OH CAS#:148017-42-9 1-Pyrrolidineca... CAS#:148017-07-6 (2S,4R)-N-tetr-...
DownStream 0

doripenem

S 4661

InterMediates of DoripeneM

(4R,5S,6S)-6-[(1R)-1-Hydroxyethyl]-4-methyl-7-oxo-3-({(3S,5S)-5-[(sulfamoylamino)methyl]-3-pyrrolidinyl}sulfanyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[(3S,5S)-5-[[(aminosulfonyl)amino]methyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-, (4R,5S,6S)-

Zhejiang Hangyu API Co., Ltd
China
Product Name: Doripenem
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Doripenem API
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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doripenem

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