2-Chloro-2'-deoxy-6-O-methylinosine

Modify Date: 2024-01-03 13:56:32

2-Chloro-2'-deoxy-6-O-methylinosine structure	Common Name	2-Chloro-2'-deoxy-6-O-methylinosine
	CAS Number	146196-07-8	Molecular Weight	300.70
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₁H₁₃ClN₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 2-Chloro-2'-deoxy-6-O-methylinosine

2-Chloro-2'-deoxy-6-O-methylinosine is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia[1][2].

Name	2-chloro-9-(2'deoxy-β-D-erythro-pentofuranosyl)-6-methoxy-9H-purine
Synonym	More Synonyms

Description	2-Chloro-2'-deoxy-6-O-methylinosine is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Virág L, Szabó C. Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15(1):99-107. [2]. Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

References

[1]. Virág L, Szabó C. Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15(1):99-107.

[2]. Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50.

Molecular Formula	C₁₁H₁₃ClN₄O₄
Molecular Weight	300.70
Exact Mass	300.06300
PSA	102.52000
LogP	0.12900

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2-Chloro-2'-deoxy-6-O-methylinosine

Use of 2-Chloro-2'-deoxy-6-O-methylinosine

Names

2-Chloro-2'-deoxy-6-O-methylinosine Biological Activity

Chemical & Physical Properties

Synonyms