2-Chloro-2'-deoxy-6-O-methylinosine

Names

[ CAS No. ]:
146196-07-8

[ Name ]:
2-Chloro-2'-deoxy-6-O-methylinosine

[Synonym ]:
(2R,3S,5R)-5-(2-Chloro-6-methoxy-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-ol
2-chloro-9-(2-deoxy-β-D-ribofuranosyl)-6-methoxy-9H-purine
2-chloro-9-(2'-deoxy-β-D-pentofuranosyl)-6-metrhoxypurine

Biological Activity

[Description]:

2-Chloro-2'-deoxy-6-O-methylinosine is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Virág L, Szabó C. Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15(1):99-107.  

[2]. Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50.  

Chemical & Physical Properties

[ Molecular Formula ]:
C11H13ClN4O4

[ Molecular Weight ]:
300.70

[ Exact Mass ]:
300.06300

[ PSA ]:
102.52000

[ LogP ]:
0.12900

Related Compounds

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