MI-2-2

Modify Date: 2024-01-02 17:04:38

MI-2-2 structure	Common Name	MI-2-2
	CAS Number	1454920-20-7	Molecular Weight	415.499
	Density	1.5±0.1 g/cm3	Boiling Point	515.1±60.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₂₀F₃N₅S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	265.3±32.9 °C

Use of MI-2-2

MI-2-2 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity (Kd=22nM) and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and very pronounced activity in MLL leukemia cells, including inhibition of cell proliferation, down-regulation of Hoxa9 expression, and differentiation[1].

Name	4-[4-(5,5-Dimethyl-4,5-dihydro-1,3-thiazol-2-yl)-1-piperazinyl]-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine
Synonym	More Synonyms

Description	MI-2-2 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity (Kd=22nM) and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and very pronounced activity in MLL leukemia cells, including inhibition of cell proliferation, down-regulation of Hoxa9 expression, and differentiation[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
In Vitro	MI-2-2 is capable of inhibiting both the interaction of menin with MBM1 (IC50= 46 nM) and with the bivalent fragment of MLL that comprises both MBM1 and MBM2 (IC50=520 nM). MI-2-2 exhibits very pronounced activities at low micromolar concentrations in BMCs transformed with MLL-AF9 and in MV4;11, a human leukemia cell line harboring the MLL-AF4 translocation[1].
References	[1]. Shi A, et al. Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia. Blood. 2012;120(23):4461-4469.

Density	1.5±0.1 g/cm3
Boiling Point	515.1±60.0 °C at 760 mmHg
Molecular Formula	C₁₇H₂₀F₃N₅S₂
Molecular Weight	415.499
Flash Point	265.3±32.9 °C
Exact Mass	415.111206
LogP	2.22
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.680
Storage condition	2-8°C

Thieno[2,3-d]pyrimidine, 4-[4-(4,5-dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(2,2,2-trifluoroethyl)-

4-[4-(5,5-Dimethyl-4,5-Dihydro-1,3-Thiazol-2-Yl)piperazin-1-Yl]-6-(2,2,2-Trifluoroethyl)thieno[2,3-D]pyrimidine

4-[4-(5,5-Dimethyl-4,5-dihydro-1,3-thiazol-2-yl)-1-piperazinyl]-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine

MFCD29044864

DC Chemicals Limited
China
Product Name: MI-2-2
Price: $400.0/5mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-(4-(5,5-dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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