OHM1
Modify Date: 2024-02-23 15:49:46
OHM1 structure
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Common Name | OHM1 | ||
|---|---|---|---|---|
| CAS Number | 1450995-09-1 | Molecular Weight | 494.637 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H42N6O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of OHM1OHM1 is a potent HIF1α mimic that binds to CH1 domain of p300/CBP with Kd of 500 nM, reduces the level of HIF1α transcriptional activity under hypoxia to that observed under normoxia at 20 uM in A549 cells; reduces the median tumor volume in murine tumor xenografts, and does not cause measurable changes in animal body weight or other signs of toxicity in tumor-bearing animals. |
| Name | OHM1 |
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| Description | OHM1 is a potent HIF1α mimic that binds to CH1 domain of p300/CBP with Kd of 500 nM, reduces the level of HIF1α transcriptional activity under hypoxia to that observed under normoxia at 20 uM in A549 cells; reduces the median tumor volume in murine tumor xenografts, and does not cause measurable changes in animal body weight or other signs of toxicity in tumor-bearing animals. |
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| References | References 1. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14. 2. Lao BB, et al. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7531-6. 3. Fang Y, et al. Exp Cell Res. 2007 Mar 10;313(5):867-77. View Related Products by Target HIF/HIF Prolyl-hydroxylase |
| Molecular Formula | C24H42N6O5 |
|---|---|
| Molecular Weight | 494.637 |