OHM1

OHM1 is a potent HIF1α mimic that binds to CH1 domain of p300/CBP with Kd of 500 nM, reduces the level of HIF1α transcriptional activity under hypoxia to that observed under normoxia at 20 uM in A549 cells; reduces the median tumor volume in murine tumor xenografts, and does not cause measurable changes in animal body weight or other signs of toxicity in tumor-bearing animals.

References 1. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14. 2. Lao BB, et al. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7531-6. 3. Fang Y, et al. Exp Cell Res. 2007 Mar 10;313(5):867-77. View Related Products by Target HIF/HIF Prolyl-hydroxylase