1450995-09-1
1450995-09-1 structure
- Name: OHM1
- Chemical Name: OHM1
- CAS Number: 1450995-09-1
- Molecular Formula: C24H42N6O5
- Molecular Weight: 494.637
- Catalog: Signaling Pathways Metabolic Enzyme/Protease HIF/HIF Prolyl-Hydroxylase
- Create Date: 2020-01-20 15:13:56
- Modify Date: 2024-02-23 15:49:46
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OHM1 is a potent HIF1α mimic that binds to CH1 domain of p300/CBP with Kd of 500 nM, reduces the level of HIF1α transcriptional activity under hypoxia to that observed under normoxia at 20 uM in A549 cells; reduces the median tumor volume in murine tumor xenografts, and does not cause measurable changes in animal body weight or other signs of toxicity in tumor-bearing animals.
| Name | OHM1 |
|---|
| Description | OHM1 is a potent HIF1α mimic that binds to CH1 domain of p300/CBP with Kd of 500 nM, reduces the level of HIF1α transcriptional activity under hypoxia to that observed under normoxia at 20 uM in A549 cells; reduces the median tumor volume in murine tumor xenografts, and does not cause measurable changes in animal body weight or other signs of toxicity in tumor-bearing animals. |
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| References | References 1. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14. 2. Lao BB, et al. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7531-6. 3. Fang Y, et al. Exp Cell Res. 2007 Mar 10;313(5):867-77. View Related Products by Target HIF/HIF Prolyl-hydroxylase |
| Molecular Formula | C24H42N6O5 |
|---|---|
| Molecular Weight | 494.637 |