MMV666810

Modify Date: 2024-04-11 18:22:13

MMV666810 Structure
MMV666810 structure
Common Name MMV666810
CAS Number 1450666-97-3 Molecular Weight 442.43
Density N/A Boiling Point N/A
Molecular Formula C23H21F3N4O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MMV666810


MMV666810, a 2-aminopyrazine similar to MMV390048, is potent against asexual parasites at 5.94 nM, but against gametocytes, it has a 3.3-fold selectivity to late-stage gametocytes compared to earlier stages (early-stage gametocyte: IC50 603 ± 88 nM; late-stage gametocyte: IC50 179 ± 8 nM).

 Names

Name MMV666810

 MMV666810 Biological Activity

Description MMV666810, a 2-aminopyrazine similar to MMV390048, is potent against asexual parasites at 5.94 nM, but against gametocytes, it has a 3.3-fold selectivity to late-stage gametocytes compared to earlier stages (early-stage gametocyte: IC50 603 ± 88 nM; late-stage gametocyte: IC50 179 ± 8 nM).
References

[1]. Niemand J, et al. Chemogenomic Fingerprints Associated with Stage-Specific Gametocytocidal Compound Action against Human Malaria Parasites. ACS Infect Dis. 2021 Oct 8;7(10):2904-2916.

 Chemical & Physical Properties

Molecular Formula C23H21F3N4O2
Molecular Weight 442.43
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