MMV666810

Names

[ Name ]:
MMV666810

Biological Activity

[Description]:

MMV666810, a 2-aminopyrazine similar to MMV390048, is potent against asexual parasites at 5.94 nM, but against gametocytes, it has a 3.3-fold selectivity to late-stage gametocytes compared to earlier stages (early-stage gametocyte: IC50 603 ± 88 nM; late-stage gametocyte: IC50 179 ± 8 nM).

[References]

[1]. Niemand J, et al. Chemogenomic Fingerprints Associated with Stage-Specific Gametocytocidal Compound Action against Human Malaria Parasites. ACS Infect Dis. 2021 Oct 8;7(10):2904-2916.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₁F₃N₄O₂

[ Molecular Weight ]:
442.43

Related Compounds

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