ACT-672125

Modify Date: 2025-12-18 17:59:15

ACT-672125 Structure
ACT-672125 structure
Common Name ACT-672125
CAS Number 1449367-94-5 Molecular Weight 586.59
Density N/A Boiling Point N/A
Molecular Formula C25H25F3N10O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ACT-672125


ACT-672125 is a potent CXCR3 antagonist with IC50 value of 239 nM in human blood. ACT-672125 has activity for hERG with IC50 value of 18μM. ACT-672125 can be used for the research of autoimmune diseases[1].

 Names

Name ACT-672125

 ACT-672125 Biological Activity

Description ACT-672125 is a potent CXCR3 antagonist with IC50 value of 239 nM in human blood. ACT-672125 has activity for hERG with IC50 value of 18μM. ACT-672125 can be used for the research of autoimmune diseases[1].
Related Catalog
Target

IC50: 239 nM (CXCR3); 18 μM (hERG)[1].

References

[1]. Caroff E, et al. Design, Synthesis, and Pharmacological Evaluation of Benzimidazolo-thiazoles as Potent CXCR3 Antagonists with Therapeutic Potential in Autoimmune Diseases: Discovery of ACT-672125. J Med Chem. 2022 Sep 8;65(17):11533-11549.  

 Chemical & Physical Properties

Molecular Formula C25H25F3N10O2S
Molecular Weight 586.59
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