ACT-672125

Names

[ Name ]:
ACT-672125

Biological Activity

[Description]:

ACT-672125 is a potent CXCR3 antagonist with IC50 value of 239 nM in human blood. ACT-672125 has activity for hERG with IC50 value of 18μM. ACT-672125 can be used for the research of autoimmune diseases[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CXCR

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> CXCR

[Target]

IC50: 239 nM (CXCR3); 18 μM (hERG)[1].

[References]

[1]. Caroff E, et al. Design, Synthesis, and Pharmacological Evaluation of Benzimidazolo-thiazoles as Potent CXCR3 Antagonists with Therapeutic Potential in Autoimmune Diseases: Discovery of ACT-672125. J Med Chem. 2022 Sep 8;65(17):11533-11549.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₅F₃N₁₀O₂S

[ Molecular Weight ]:
586.59

Related Compounds

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