1449367-94-5

1449367-94-5 structure

1449367-94-5 structure

Name: ACT-672125
Chemical Name: ACT-672125
CAS Number: 1449367-94-5
Molecular Formula: C₂₅H₂₅F₃N₁₀O₂S
Molecular Weight: 586.59
Catalog: Signaling Pathways GPCR/G Protein CXCR
Create Date: 2023-09-27 11:15:01
Modify Date: 2024-01-31 21:50:24
ACT-672125 is a potent CXCR3 antagonist with IC50 value of 239 nM in human blood. ACT-672125 has activity for hERG with IC50 value of 18μM. ACT-672125 can be used for the research of autoimmune diseases[1].

Name	ACT-672125

Description	ACT-672125 is a potent CXCR3 antagonist with IC50 value of 239 nM in human blood. ACT-672125 has activity for hERG with IC50 value of 18μM. ACT-672125 can be used for the research of autoimmune diseases[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CXCR Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> CXCR
Target	IC50: 239 nM (CXCR3); 18 μM (hERG)[1].
References	[1]. Caroff E, et al. Design, Synthesis, and Pharmacological Evaluation of Benzimidazolo-thiazoles as Potent CXCR3 Antagonists with Therapeutic Potential in Autoimmune Diseases: Discovery of ACT-672125. J Med Chem. 2022 Sep 8;65(17):11533-11549.

Molecular Formula	C₂₅H₂₅F₃N₁₀O₂S
Molecular Weight	586.59