(2S,3S)-3-[N-(Quinoxaline-2-carbonyl)-L-asparaginyl]amino-2-hydroxy-4- phenylbutanoyl-L-proline, tert-butylamide
Modify Date: 2025-09-13 09:09:16
![(2S,3S)-3-[N-(Quinoxaline-2-carbonyl)-L-asparaginyl]amino-2-hydroxy-4- phenylbutanoyl-L-proline, tert-butylamide Structure](https://image.chemsrc.com/caspic/389/144779-91-9.png)
(2S,3S)-3-[N-(Quinoxaline-2-carbonyl)-L-asparaginyl]amino-2-hydroxy-4- phenylbutanoyl-L-proline, tert-butylamide structure
|
Common Name | (2S,3S)-3-[N-(Quinoxaline-2-carbonyl)-L-asparaginyl]amino-2-hydroxy-4- phenylbutanoyl-L-proline, tert-butylamide | ||
|---|---|---|---|---|
| CAS Number | 144779-91-9 | Molecular Weight | 617.69500 | |
| Density | 1.311g/cm3 | Boiling Point | 1055.5ºC at 760 mmHg | |
| Molecular Formula | C32H39N7O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 592.1ºC | |
Use of (2S,3S)-3-[N-(Quinoxaline-2-carbonyl)-L-asparaginyl]amino-2-hydroxy-4- phenylbutanoyl-L-proline, tert-butylamideR-87366 is a water-soluble human immunodeficiency virus (HIV) protease inhibitor. R-87366 has potent inhibitory for HIV protease with a Ki value of 11 nM. R-87366 can be used for the research of anti-human immunodeficiency virus (HIV)[1]. |
| Name | (2S)-N-[(2S,3S)-4-[(2S)-2-(tert-butylcarbamoyl)pyrrolidin-1-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]-2-(quinoxaline-2-carbonylamino)butanediamide |
|---|---|
| Synonym | More Synonyms |
| Description | R-87366 is a water-soluble human immunodeficiency virus (HIV) protease inhibitor. R-87366 has potent inhibitory for HIV protease with a Ki value of 11 nM. R-87366 can be used for the research of anti-human immunodeficiency virus (HIV)[1]. |
|---|---|
| Related Catalog | |
| Target |
Ki: 11 nM (HIV protease)[1]. IC90: 0.5 μM (HIV-1IIIB acutely infected cells)[1] |
| In Vitro | R-87366 对人类免疫缺陷病毒蛋白酶具有强效抑制作用，Ki 值为 11 nM[1]。 R-87366 对 HIV-1IIIB 急性感染细胞具有活性，IC90 值为 0.5 μM[1]。 R-87366 具有中等水溶性[1]。 R-87366 (0.25 μM; 0.5 μM) 对慢性感染的 Molt-4/HIV-1IIIB 细胞也有活性，并抑制 p55 蛋白水解加工成 p17[1]。 |
| References |
| Density | 1.311g/cm3 |
|---|---|
| Boiling Point | 1055.5ºC at 760 mmHg |
| Molecular Formula | C32H39N7O6 |
| Molecular Weight | 617.69500 |
| Flash Point | 592.1ºC |
| Exact Mass | 617.29600 |
| PSA | 208.17000 |
| LogP | 3.94070 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.622 |
| InChIKey | UYZMZENNYRSFDS-QNWDWTFCSA-N |
| SMILES | CC(C)(C)NC(=O)C1CCCN1C(=O)C(O)C(Cc1ccccc1)NC(=O)C(CC(N)=O)NC(=O)c1cnc2ccccc2n1 |
| AHPBA analog |