(2S,3S)-3-[N-(Quinoxaline-2-carbonyl)-L-asparaginyl]amino-2-hydroxy-4- phenylbutanoyl-L-proline, tert-butylamide

Names

[ Name ]:
(2S,3S)-3-[N-(Quinoxaline-2-carbonyl)-L-asparaginyl]amino-2-hydroxy-4- phenylbutanoyl-L-proline, tert-butylamide

[Synonym ]:
AHPBA analog

Biological Activity

[Description]:

R-87366 is a water-soluble human immunodeficiency virus (HIV) protease inhibitor. R-87366 has potent inhibitory for HIV protease with a Ki value of 11 nM. R-87366 can be used for the research of anti-human immunodeficiency virus (HIV)[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Protease

[Target]

Ki: 11 nM (HIV protease)[1]. IC90: 0.5 μM (HIV-1IIIB acutely infected cells)[1]

[In Vitro]

R-87366 对人类免疫缺陷病毒蛋白酶具有强效抑制作用，Ki 值为 11 nM[1]。 R-87366 对 HIV-1IIIB 急性感染细胞具有活性，IC90 值为 0.5 μM[1]。 R-87366 具有中等水溶性[1]。 R-87366 (0.25 μM; 0.5 μM) 对慢性感染的 Molt-4/HIV-1IIIB 细胞也有活性，并抑制 p55 蛋白水解加工成 p17[1]。

[References]

[1]. T Komai, et al. In vitro and ex vivo anti-human immunodeficiency virus (HIV) activities of a new water-soluble HIV protease inhibitor, R-87366, containing (2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid. Biol Pharm Bull. 1997 Feb;20(2):175-80.

Chemical & Physical Properties

[ Density]:
1.311g/cm3

[ Boiling Point ]:
1055.5ºC at 760 mmHg

[ Molecular Formula ]:
C₃₂H₃₉N₇O₆

[ Molecular Weight ]:
617.69500

[ Flash Point ]:
592.1ºC

[ Exact Mass ]:
617.29600

[ PSA ]:
208.17000

[ LogP ]:
3.94070

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.622

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.