DFL 23448

Modify Date: 2024-02-22 19:51:00

DFL 23448 Structure
DFL 23448 structure
 Common Name DFL 23448
CAS Number 1445753-16-1 Molecular Weight 291.304
Density N/A Boiling Point N/A
Molecular Formula C12H10FN5OS Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DFL 23448


A novel potent, selective TRPM8 channel antagonist with IC50 of 10 and 21 nM in hTRPM8 HEK293 cells activated by Cooling Agent 10 or cold; exhibits limited activity (IC50 >10 μM) at TRPV1, TRPA1, TRPV4 and at various G protein-coupled receptors; reduces icilin-induced "wet dog-like" shakes, reduces bladder overactivity in awake rats.

 Names

Name DFL 23448

 DFL 23448 Biological Activity

Description A novel potent, selective TRPM8 channel antagonist with IC50 of 10 and 21 nM in hTRPM8 HEK293 cells activated by Cooling Agent 10 or cold; exhibits limited activity (IC50 >10 μM) at TRPV1, TRPA1, TRPV4 and at various G protein-coupled receptors; reduces icilin-induced "wet dog-like" shakes, reduces bladder overactivity in awake rats.
References References 1. Mistretta FA, et al. J Pharmacol Exp Ther. 2016 Jan;356(1):200-11. View Related Products by Target TRP Channel

 Chemical & Physical Properties

Molecular Formula C12H10FN5OS
Molecular Weight 291.304
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Chemsrc provides DFL 23448(CAS#:1445753-16-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of DFL 23448 are included as well.>> amp version: DFL 23448

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