DFL 23448
Modify Date: 2024-02-22 19:51:00
DFL 23448 structure
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Common Name | DFL 23448 | ||
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| CAS Number | 1445753-16-1 | Molecular Weight | 291.304 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H10FN5OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DFL 23448A novel potent, selective TRPM8 channel antagonist with IC50 of 10 and 21 nM in hTRPM8 HEK293 cells activated by Cooling Agent 10 or cold; exhibits limited activity (IC50 >10 μM) at TRPV1, TRPA1, TRPV4 and at various G protein-coupled receptors; reduces icilin-induced "wet dog-like" shakes, reduces bladder overactivity in awake rats. |
| Name | DFL 23448 |
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| Description | A novel potent, selective TRPM8 channel antagonist with IC50 of 10 and 21 nM in hTRPM8 HEK293 cells activated by Cooling Agent 10 or cold; exhibits limited activity (IC50 >10 μM) at TRPV1, TRPA1, TRPV4 and at various G protein-coupled receptors; reduces icilin-induced "wet dog-like" shakes, reduces bladder overactivity in awake rats. |
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| References | References 1. Mistretta FA, et al. J Pharmacol Exp Ther. 2016 Jan;356(1):200-11. View Related Products by Target TRP Channel |
| Molecular Formula | C12H10FN5OS |
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| Molecular Weight | 291.304 |