DFL 23448

Names

[ Name ]:
DFL 23448

Biological Activity

[Description]:

A novel potent, selective TRPM8 channel antagonist with IC50 of 10 and 21 nM in hTRPM8 HEK293 cells activated by Cooling Agent 10 or cold; exhibits limited activity (IC50 >10 μM) at TRPV1, TRPA1, TRPV4 and at various G protein-coupled receptors; reduces icilin-induced "wet dog-like" shakes, reduces bladder overactivity in awake rats.

[References]

References 1. Mistretta FA, et al. J Pharmacol Exp Ther. 2016 Jan;356(1):200-11. View Related Products by Target TRP Channel

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₀FN₅OS

[ Molecular Weight ]:
291.304

Related Compounds

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