1445753-16-1
1445753-16-1 structure
- Name: DFL 23448
- Chemical Name: DFL 23448
- CAS Number: 1445753-16-1
- Molecular Formula: C12H10FN5OS
- Molecular Weight: 291.304
- Create Date: 2020-01-20 10:33:56
- Modify Date: 2024-02-22 19:51:00
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A novel potent, selective TRPM8 channel antagonist with IC50 of 10 and 21 nM in hTRPM8 HEK293 cells activated by Cooling Agent 10 or cold; exhibits limited activity (IC50 >10 μM) at TRPV1, TRPA1, TRPV4 and at various G protein-coupled receptors; reduces icilin-induced "wet dog-like" shakes, reduces bladder overactivity in awake rats.
| Name | DFL 23448 |
|---|
| Description | A novel potent, selective TRPM8 channel antagonist with IC50 of 10 and 21 nM in hTRPM8 HEK293 cells activated by Cooling Agent 10 or cold; exhibits limited activity (IC50 >10 μM) at TRPV1, TRPA1, TRPV4 and at various G protein-coupled receptors; reduces icilin-induced "wet dog-like" shakes, reduces bladder overactivity in awake rats. |
|---|---|
| References | References 1. Mistretta FA, et al. J Pharmacol Exp Ther. 2016 Jan;356(1):200-11. View Related Products by Target TRP Channel |
| Molecular Formula | C12H10FN5OS |
|---|---|
| Molecular Weight | 291.304 |