TFMB-(R)-2-HG

Modify Date: 2025-09-18 18:38:03

TFMB-(R)-2-HG Structure
TFMB-(R)-2-HG structure
Common Name TFMB-(R)-2-HG
CAS Number 1445700-01-5 Molecular Weight 288.219
Density 1.4±0.1 g/cm3 Boiling Point 376.3±42.0 °C at 760 mmHg
Molecular Formula C13H11F3O4 Melting Point N/A
MSDS N/A Flash Point 175.2±22.8 °C

 Use of TFMB-(R)-2-HG


TFMB-(R)-2-HG, a cell membrane-permeable version of (R)-2-HG, is a carcinogenic factor in Acute myeloid leukemia (AML).TFMB-(R)-2-HG impairs SCF ER-Hoxb8 cells differentiation in response to estrogen withdrawal[1].

 Names

Name 3-(Trifluoromethyl)benzyl (2R)-5-oxotetrahydro-2-furancarboxylate
Synonym More Synonyms

 TFMB-(R)-2-HG Biological Activity

Description TFMB-(R)-2-HG, a cell membrane-permeable version of (R)-2-HG, is a carcinogenic factor in Acute myeloid leukemia (AML).TFMB-(R)-2-HG impairs SCF ER-Hoxb8 cells differentiation in response to estrogen withdrawal[1].
Related Catalog
References

[1]. Losman JA, et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013 Mar 29;339(6127):1621-5.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 376.3±42.0 °C at 760 mmHg
Molecular Formula C13H11F3O4
Molecular Weight 288.219
Flash Point 175.2±22.8 °C
Exact Mass 288.060944
LogP 1.14
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.494
InChIKey UXTLNUGKDZMPTC-SNVBAGLBSA-N
SMILES O=C1CCC(C(=O)OCc2cccc(C(F)(F)F)c2)O1

 Synonyms

3-(Trifluoromethyl)benzyl (2R)-5-oxotetrahydro-2-furancarboxylate
2-Furancarboxylic acid, tetrahydro-5-oxo-, [3-(trifluoromethyl)phenyl]methyl ester, (2R)-
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