TFMB-(R)-2-HG

Names

[ Name ]:
TFMB-(R)-2-HG

[Synonym ]:
3-(Trifluoromethyl)benzyl (2R)-5-oxotetrahydro-2-furancarboxylate
2-Furancarboxylic acid, tetrahydro-5-oxo-, [3-(trifluoromethyl)phenyl]methyl ester, (2R)-

Biological Activity

[Description]:

TFMB-(R)-2-HG, a cell membrane-permeable version of (R)-2-HG, is a carcinogenic factor in Acute myeloid leukemia (AML).TFMB-(R)-2-HG impairs SCF ER-Hoxb8 cells differentiation in response to estrogen withdrawal[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Losman JA, et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013 Mar 29;339(6127):1621-5.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
376.3±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₁F₃O₄

[ Molecular Weight ]:
288.219

[ Flash Point ]:
175.2±22.8 °C

[ Exact Mass ]:
288.060944

[ LogP ]:
1.14

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.494

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.