Licochalcone C

Modify Date: 2024-01-03 09:08:04

Licochalcone C structure	Common Name	Licochalcone C
	CAS Number	144506-14-9	Molecular Weight	338.397
	Density	1.2±0.1 g/cm3	Boiling Point	536.1±50.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₂₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	188.4±23.6 °C

Use of Licochalcone C

Licochalcone C could inhibit α-glucosidase, with IC50s of <100 nM and 92.43 μM for α-glucosidase and protein tyrosine phosphatase 1B (PTP1B), respectively.

Name	(E)-3-[4-hydroxy-2-methoxy-3-(3-methylbut-2-enyl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
Synonym	More Synonyms

Description	Licochalcone C could inhibit α-glucosidase, with IC50s of <100 nM and 92.43 μM for α-glucosidase and protein tyrosine phosphatase 1B (PTP1B), respectively.
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Flavonoids Research Areas >> Metabolic Disease
Target	IC50: <100 nM (α-glucosidase), 92.43 μM (PTP1B)[1].
In Vitro	Licochalcone C could inhibit α- glucosidase, with IC50s of <100 nM and 92.43 μM for α- glucosidase and PTP1B, respectively[1]. It is also indicated that Licochalcone C induces T24 cell apoptosis in a concentration‑dependent manner. Licochalcone C treatment reduces the levels of the anti‑apoptotic mRNAs (Bcl-2, Bcl-w and Bcl-XL) and increases expression of the pro-apoptotic mRNAs (Bax and Bim). The Bcl-2 family inhibitor (ABT-737) reduces apoptosis induced by licochalcone C in T24 cells[2].
References	[1]. Zhenghong Guo, et al. Chemical profile and inhibition of α-glycosidase and protein tyrosine phosphatase 1B (PTP1B) activities by flavonoids from licorice (Glycyrrhiza uralensis Fisch). journal of functional foods 14 ( 2015 ) 324-336. [2]. PENGLONG WANG, et al. Licochalcone C induces apoptosis via B-cell lymphoma 2 family proteins in T24 cells. Mol Med Rep. 2015 Nov;12(5):7623-8.

Density	1.2±0.1 g/cm3
Boiling Point	536.1±50.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₂O₄
Molecular Weight	338.397
Flash Point	188.4±23.6 °C
Exact Mass	338.151794
PSA	66.76000
LogP	5.33
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.622
Storage condition	2-8C

2-Propen-1-one, 3-[4-hydroxy-2-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-1-(4-hydroxyphenyl)-, (2E)-

(2E)-3-[4-hydroxy-2-methoxy-3-(3-methylbut-2-en-1-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one

Y0122

(2E)-3-[4-Hydroxy-2-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-1-(4-hydroxyphenyl)-2-propen-1-one

Licochalcone C

UNII-P1H7W3812O

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Licochalcone C
Price: ￥2948.0/10mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Licochalcone C
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: ￥1900/1 mg

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Licochalcone C

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