1-Deazaadenosine

Modify Date: 2024-01-03 16:16:20

1-Deazaadenosine structure	Common Name	1-Deazaadenosine
	CAS Number	14432-09-8	Molecular Weight	266.25300
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₁H₁₄N₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 1-Deazaadenosine

1-Deazaadenosine is a potent Adenosine deaminase (ADA) inhibitor with a Ki value of 0.66 μM. 1-Deazaadenosine exhibits anti-cancer activities in vitro and has the potential to be a chemotherapy agent for lymphoproliferative disorders[1][2].

Name	1-deazaadenosine
Synonym	More Synonyms

Description	1-Deazaadenosine is a potent Adenosine deaminase (ADA) inhibitor with a Ki value of 0.66 μM. 1-Deazaadenosine exhibits anti-cancer activities in vitro and has the potential to be a chemotherapy agent for lymphoproliferative disorders[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Adenosine Deaminase
In Vitro	1-Deazaadenosine shows good activity in vitro as inhibitor of HeLa, KB, P388, and L1210 leukemia cell line growth, with ID50 values ranging from 0.34 μM (KB) to 1.8 μM (P388)[2].
References	[1]. Cristalli G, et al.Adenosine deaminase inhibitors: Structure-activity relationships in 1-deazaadenosine and erythro-9-(2-hydroxy-3-nonyl)adenine analogues. Drug Dev.Res. [2]. Cristalli G, et al.Improved synthesis and antitumor activity of 1-deazaadenosine.J Med Chem. 1987 Sep;30(9):1686-8.

Molecular Formula	C₁₁H₁₄N₄O₄
Molecular Weight	266.25300
Exact Mass	266.10200
PSA	126.65000

7-Amino-3-(β-D-ribofuranosyl)imidazo[4,5-b]pyridine

1-deaza-adenosine

1-(7-amino-imidazo[4,5-b]pyridin-3-yl)-β-D-1-deoxy-ribofuranose

1-Deazaadenosine

1-Deazaadenosine

Use of 1-Deazaadenosine

Names

1-Deazaadenosine Biological Activity

Chemical & Physical Properties

Synonyms