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1-Deazaadenosine

Names

[ CAS No. ]:
14432-09-8

[ Name ]:
1-Deazaadenosine

[Synonym ]:
7-Amino-3-(β-D-ribofuranosyl)imidazo[4,5-b]pyridine
1-deaza-adenosine
1-(7-amino-imidazo[4,5-b]pyridin-3-yl)-β-D-1-deoxy-ribofuranose
1-Deazaadenosine

Biological Activity

[Description]:

1-Deazaadenosine is a potent Adenosine deaminase (ADA) inhibitor with a Ki value of 0.66 μM. 1-Deazaadenosine exhibits anti-cancer activities in vitro and has the potential to be a chemotherapy agent for lymphoproliferative disorders[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Adenosine Deaminase

[In Vitro]

1-Deazaadenosine shows good activity in vitro as inhibitor of HeLa, KB, P388, and L1210 leukemia cell line growth, with ID50 values ranging from 0.34 μM (KB) to 1.8 μM (P388)[2].

[References]

[1]. Cristalli G, et al.Adenosine deaminase inhibitors: Structure-activity relationships in 1-deazaadenosine and erythro-9-(2-hydroxy-3-nonyl)adenine analogues. Drug Dev.Res.

[2]. Cristalli G, et al.Improved synthesis and antitumor activity of 1-deazaadenosine.J Med Chem. 1987 Sep;30(9):1686-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C11H14N4O4

[ Molecular Weight ]:
266.25300

[ Exact Mass ]:
266.10200

[ PSA ]:
126.65000

Related Compounds