TWIK-1/TREK-1-IN-1

Modify Date: 2024-10-01 11:41:52

TWIK-1/TREK-1-IN-1 structure	Common Name	TWIK-1/TREK-1-IN-1
	CAS Number	1440532-30-8	Molecular Weight	395.42
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₄F₃NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TWIK-1/TREK-1-IN-1

TWIK-1/TREK-1-IN-1 (compound 2a) is an inhibitor of the TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.36 μM and 14.6 μM, respectively, and has antidepressant-like effects[1].

Name	TWIK-1/TREK-1-IN-1

Description	TWIK-1/TREK-1-IN-1 (compound 2a) is an inhibitor of the TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.36 μM and 14.6 μM, respectively, and has antidepressant-like effects[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	IC50: 9.36 μM (TREK-1/TREK-1), 14.6 μM (TWIK-1/TREK-1)[1]
References	[1]. Lee EH, et al. Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants. Biomed Pharmacother. 2023 Sep;165:115139.. .

Molecular Formula	C₂₁H₂₄F₃NO₃
Molecular Weight	395.42

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TWIK-1/TREK-1-IN-1

Use of TWIK-1/TREK-1-IN-1

Names

TWIK-1/TREK-1-IN-1 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.