1440532-30-8
1440532-30-8 structure
- Name: TWIK-1/TREK-1-IN-1
- Chemical Name: TWIK-1/TREK-1-IN-1
- CAS Number: 1440532-30-8
- Molecular Formula: C21H24F3NO3
- Molecular Weight: 395.42
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
- Create Date: 2024-10-01 11:41:52
- Modify Date: 2024-10-01 11:41:52
-
TWIK-1/TREK-1-IN-1 (compound 2a) is an inhibitor of the TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.36 μM and 14.6 μM, respectively, and has antidepressant-like effects[1].
| Name | TWIK-1/TREK-1-IN-1 |
|---|
| Description | TWIK-1/TREK-1-IN-1 (compound 2a) is an inhibitor of the TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.36 μM and 14.6 μM, respectively, and has antidepressant-like effects[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 9.36 μM (TREK-1/TREK-1), 14.6 μM (TWIK-1/TREK-1)[1] |
| References |
| Molecular Formula | C21H24F3NO3 |
|---|---|
| Molecular Weight | 395.42 |