Antibiotic 1142

Modify Date: 2025-08-21 14:31:16

Antibiotic 1142 Structure
Antibiotic 1142 structure
 Common Name Antibiotic 1142
CAS Number 1438-30-8 Molecular Weight 430.46400
Density 1.52g/cm3 Boiling Point 544.74°C (rough estimate)
Molecular Formula C18H26N10O3 Melting Point 171-173℃
MSDS N/A Flash Point N/A

 Use of Antibiotic 1142


Netropsin is a basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics research. Netropsin is a polyamide with antibiotic and antiviral activity. It has been shown that Netropsin is active both against Gram-positive bacteria and Gram-negative bacteria.

 Names

Name netropsin
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.52g/cm3
Boiling Point 544.74°C (rough estimate)
Melting Point 171-173℃
Molecular Formula C18H26N10O3
Molecular Weight 430.46400
Exact Mass 430.21900
PSA 208.93000
LogP 1.62120
Appearance of Characters powder | faint yellow
Vapour Pressure 1.75E-23mmHg at 25°C
Index of Refraction 1.6500 (estimate)
Storage condition −20°C
Water Solubility H2O: 1 mg/mL

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DW2973000
CHEMICAL NAME :
N,4'-Bi(pyrrole-2-carboxamide), N'-(2-carbamoylethyl)-4-((2-guanidinoacetimidoyl)amin o)-1,1'- dimethyl-
CAS REGISTRY NUMBER :
1438-30-8
BEILSTEIN REFERENCE NO. :
0376913
LAST UPDATED :
199612
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C18-H26-N10-O3
MOLECULAR WEIGHT :
430.54
WISWESSER LINE NOTATION :
T5NJ A1 BVM2VZ EMV- BT5NJ A1 DMYUM&1MYZUM

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
70 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
17 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Mammal - species unspecified Lymphocyte
DOSE/DURATION :
500 umol/L
REFERENCE :
MLBRBU Molecular Biology Reports. (Dr. W. Junk Pub., POB 163, 3300 AD Dordrect, Netherlands) V.1- 1973- Volume(issue)/page/year: 2,135,1975

 Safety Information

Hazard Codes Xn: Harmful;
Risk Phrases R22
Safety Phrases S36
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS DW2973000

 Synonyms

4-{4-[(N-carbamimidoyl-glycyl)-amino]-1-methyl-pyrrole-2-carbonylamino}-1-methyl-pyrrole-2-carboxylic acid-(2-carbamimidoyl-ethylamide)
t1384
Netropsin dihydrochloride
ia887
4-{4-[(N-Carbamimidoyl-glycyl)-amino]-1-methyl-pyrrol-2-carbonylamino}-1-methyl-pyrrol-2-carbonsaeure-(2-carbamimidoyl-aethylamid)
ch-777-a
Congocidin Sinanomycin
congocidin
ultrapuregrade
2814-a
antibiotic1142
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Chemsrc provides Antibiotic 1142(CAS#:1438-30-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Antibiotic 1142 are included as well.>> amp version: Antibiotic 1142

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