37305-78-5

37305-78-5 structure

Name: A201A
Chemical Name: (E)-3-[4-[(5Z)-3,4-dihydroxy-5-[2-(3-hydroxy-4,5-dimethoxy-6-methyloxan-2-yl)oxy-1-methoxyethylidene]oxolan-2-yl]oxyphenyl]-N-[5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-2-methylprop-2-enamide
CAS Number: 37305-78-5
Molecular Formula: C₃₇H₅₀N₆O₁₄
Molecular Weight: 802.82500
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-06-27 11:01:27
Modify Date: 2024-09-15 12:28:12
A201A is a aminoacylnucleoside antibiotic with antibacterial activities. A201A is highly effective against Gram-positive and most Gram-negative anaerobic bacteria. A201A inhibits tRNA accommodation during translation[1][2].

Name	(E)-3-[4-[(5Z)-3,4-dihydroxy-5-[2-(3-hydroxy-4,5-dimethoxy-6-methyloxan-2-yl)oxy-1-methoxyethylidene]oxolan-2-yl]oxyphenyl]-N-[5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-2-methylprop-2-enamide
Synonyms	Antibiotic A 201A A 201A

Description	A201A is a aminoacylnucleoside antibiotic with antibacterial activities. A201A is highly effective against Gram-positive and most Gram-negative anaerobic bacteria. A201A inhibits tRNA accommodation during translation[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Nie S, et al. Total synthesis of nucleoside antibiotic A201A. J Am Chem Soc. 2014 Mar 19;136(11):4157-60. [2]. Wang J, et al. Bioinspired Total Synthesis of Complex Nucleoside Antibiotics A201A, A201D and A201E. Angew Chem Int Ed Engl. 2023 Jan 16;62(3):e202213810.