Urea-d4

Modify Date: 2024-01-12 08:46:57

Urea-d4 structure	Common Name	Urea-d4
	CAS Number	1433-11-0	Molecular Weight	64.07990
	Density	1.212g/cm3	Boiling Point	196.6ºC at 760mmHg
	Molecular Formula	CD₄N₂O	Melting Point	132-135ºC(lit.)
	MSDS	Chinese USA	Flash Point	72.7ºC

Use of Urea-d4

Urea-d4 is the deuterium labeled Urea[1]. Urea is a powerful protein denaturant via both direct and indirect mechanisms[2]. A potent emollient and keratolytic agent[3]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[4]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

Name	1,1,3,3-tetradeuteriourea
Synonym	More Synonyms

Description	Urea-d4 is the deuterium labeled Urea[1]. Urea is a powerful protein denaturant via both direct and indirect mechanisms[2]. A potent emollient and keratolytic agent[3]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[4]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Bennion BJ, et al. The molecular basis for the chemical denaturation of proteins by urea. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5142-7. [3]. Pan M, et al. Urea: a comprehensive review of the clinical literature. Dermatol Online J. 2013 Nov 1519(11):20392.Wang H, et al. Urea. Subcell Biochem. 201473:7-29. [4]. Wang H, et al. Urea. Subcell Biochem. 201473:7-29.

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Bennion BJ, et al. The molecular basis for the chemical denaturation of proteins by urea. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5142-7.

[3]. Pan M, et al. Urea: a comprehensive review of the clinical literature. Dermatol Online J. 2013 Nov 1519(11):20392.Wang H, et al. Urea. Subcell Biochem. 201473:7-29.

[4]. Wang H, et al. Urea. Subcell Biochem. 201473:7-29.

Density	1.212g/cm3
Boiling Point	196.6ºC at 760mmHg
Melting Point	132-135ºC(lit.)
Molecular Formula	CD₄N₂O
Molecular Weight	64.07990
Flash Point	72.7ºC
Exact Mass	64.05750
PSA	69.11000
LogP	0.42440
Vapour Pressure	0.395mmHg at 25°C
Index of Refraction	1.468

Urea-d4 MSDS(Chinese)

Personal Protective Equipment	Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	Xn
Risk Phrases	R40;R36/37/38
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport

Differential stability of the bovine prion protein upon urea unfolding.

Protein Sci. 18(10) , 2172-82, (2009)

Prion diseases, or transmissible spongiform encephalopathies, are a group of infectious neurological diseases associated with the structural conversion of an endogenous protein (PrP) in the central ne...

Urea-d4

deuterourea

tetradeuteriourea

deuterated urea

EINECS 215-857-8

MFCD00044227

Tetradeuterio-harnstoff

Urea-d4

Use of Urea-d4

Names

Urea-d4 Biological Activity

Chemical & Physical Properties

MSDS

Safety Information

Articles1

Synonyms