Retro-2 cycl

Modify Date: 2025-08-27 06:53:24

Retro-2 cycl Structure
Retro-2 cycl structure
Common Name Retro-2 cycl
CAS Number 1429192-00-6 Molecular Weight 320.41
Density N/A Boiling Point N/A
Molecular Formula C19H16N2OS Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of Retro-2 cycl


Retro-2 cycl (RN 1-001) is a dihydroquinazolinone (DHQZ) inhibitor of retrograde trafficking. Retro-2 cycl (RN 1-001) inhibits JCPyV and HPV16 pseudovirus with IC50s of 54 μM and 160 μM, respectively[1]. Antiviral agent[1].

 Names

Name 2-(5-methylthiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one
Synonym More Synonyms

 Retro-2 cycl Biological Activity

Description Retro-2 cycl (RN 1-001) is a dihydroquinazolinone (DHQZ) inhibitor of retrograde trafficking. Retro-2 cycl (RN 1-001) inhibits JCPyV and HPV16 pseudovirus with IC50s of 54 μM and 160 μM, respectively[1]. Antiviral agent[1].
Related Catalog
References

[1]. Carney DW, et al. Structural optimization of a retrograde trafficking inhibitor that protects cells from infections by human polyoma- and papillomaviruses. Bioorg Med Chem. 2014 Sep 1;22(17):4836-47.

 Chemical & Physical Properties

Molecular Formula C19H16N2OS
Molecular Weight 320.41
Exact Mass 320.09800
PSA 60.58000
LogP 5.03060
InChIKey BOAPXDSRULBILC-UHFFFAOYSA-N
SMILES Cc1ccc(C2Nc3ccccc3C(=O)N2c2ccccc2)s1
Storage condition 2-8℃

 Safety Information

RIDADR NONH for all modes of transport

 Synonyms

rn-1-001
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