ML254

Modify Date: 2025-11-30 08:56:10

ML254 structure	Common Name	ML254
	CAS Number	1428630-86-7	Molecular Weight	310.32
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₅FN₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ML254

ML254 is a potent mGlu5 potentiator, with EC50 and pEC50 of 9.3 nM and 8.03 nM for rat mGlu5, respectively. ML254 can be used for researching schizophrenia[1].

Name	ML 254

Description	ML254 is a potent mGlu5 potentiator, with EC50 and pEC50 of 9.3 nM and 8.03 nM for rat mGlu5, respectively. ML254 can be used for researching schizophrenia[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	rat mGluR5:9.3 nM (EC50) rat mGluR5:8.03 nM (pEC50)
References	[1]. Turlington M, Noetzel MJ, Chun A, et al. Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254). J Med Chem. 2013;56(20):7976-7996.

Molecular Formula	C₁₈H₁₅FN₂O₂
Molecular Weight	310.32
InChIKey	YMYCVXPMSMNWEP-UHFFFAOYSA-N
SMILES	CC1(NC(=O)c2ccc(C#Cc3cccc(F)c3)cn2)COC1

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: ML254
Price: Check
Purity: 99.94%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: ML254
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: ML 254
Price: ￥Inquiry/100mg
Purity: 98.0%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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