ML254

Names

[ Name ]:
ML254

Biological Activity

[Description]:

ML254 is a potent mGlu5 potentiator, with EC50 and pEC50 of 9.3 nM and 8.03 nM for rat mGlu5, respectively. ML254 can be used for researching schizophrenia[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[Target]

rat mGluR5:9.3 nM (EC50)

rat mGluR5:8.03 nM (pEC50)

[References]

[1]. Turlington M, Noetzel MJ, Chun A, et al. Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254). J Med Chem. 2013;56(20):7976-7996.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₅FN₂O₂

[ Molecular Weight ]:
310.32

Related Compounds

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