IWP L6
Modify Date: 2024-01-09 08:56:55
IWP L6 structure
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Common Name | IWP L6 | ||
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| CAS Number | 1427782-89-5 | Molecular Weight | 472.582 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C25H20N4O2S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of IWP L6IWP L6 is a Porcn inhibitor with EC50 of 0.5 nM.IC50 Value: 0.5 nM(EC50) [1]Target: Porcupinein vitro: IWP-L6 effectively suppressed the phosphorylation of dishevelled 2 (Dvl2) in HEK293 cells, a biochemical event associated with many Wnt-dependent cellular responses. IWP-L6 inhibits Wnt mediated branching morphogenesis in cultured embryonic kidneys [1].in vivo: IWP-L6 is stable in human plasma over 24 h, it was rapidly metabolized in rat plasma (t1/2 = 190 min), murine plasma (t1/2 = 2 min), and the murine liver S9 fractions (t1/2 = 26 min). The major metabolites are the amide cleavage products. Similar species-dependent metabolitic profiles due to the involvement of carboxylesterase (CES) have been reported with other drug candidates. Despite its modest metabolic stability in mouse-derived plasma, IWP-L6 was highly active in zebrafish. IWP-L6 exhibited more potent activity [1]. |
| Name | 2-[(4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl) sulfanyl]-N-(5-phenyl-2-pyridinyl)acetamide |
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| Synonym | More Synonyms |
| Description | IWP L6 is a Porcn inhibitor with EC50 of 0.5 nM.IC50 Value: 0.5 nM(EC50) [1]Target: Porcupinein vitro: IWP-L6 effectively suppressed the phosphorylation of dishevelled 2 (Dvl2) in HEK293 cells, a biochemical event associated with many Wnt-dependent cellular responses. IWP-L6 inhibits Wnt mediated branching morphogenesis in cultured embryonic kidneys [1].in vivo: IWP-L6 is stable in human plasma over 24 h, it was rapidly metabolized in rat plasma (t1/2 = 190 min), murine plasma (t1/2 = 2 min), and the murine liver S9 fractions (t1/2 = 26 min). The major metabolites are the amide cleavage products. Similar species-dependent metabolitic profiles due to the involvement of carboxylesterase (CES) have been reported with other drug candidates. Despite its modest metabolic stability in mouse-derived plasma, IWP-L6 was highly active in zebrafish. IWP-L6 exhibited more potent activity [1]. |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
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| Molecular Formula | C25H20N4O2S2 |
| Molecular Weight | 472.582 |
| Exact Mass | 472.102753 |
| PSA | 130.97000 |
| LogP | 5.64 |
| Index of Refraction | 1.727 |
| Storage condition | -20℃ |
| Acetamide, N-(5-phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]- |
| 2-[(4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(5-phenyl-2-pyridinyl)acetamide |
| IWP L6 |