IWP-3
Modify Date: 2025-08-27 06:42:23
IWP-3 structure
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Common Name | IWP-3 | ||
|---|---|---|---|---|
| CAS Number | 687561-60-0 | Molecular Weight | 484.589 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C22H17FN4O2S3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of IWP-3IWP-3 is an potent inhibitor of Wnt production with an IC50 of 40 nM. IWP-3 inhibits Porcupine (Porcn) function thereby blocking palmitoylation of Wnt proteins. IWP-3 inhibits CK1γ3 and CK1ε only moderately and does not inhibit CK1α[1][2]. |
| Name | 2-{[3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrim idin-2-yl]sulfanyl}-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide |
|---|---|
| Synonym | More Synonyms |
| Description | IWP-3 is an potent inhibitor of Wnt production with an IC50 of 40 nM. IWP-3 inhibits Porcupine (Porcn) function thereby blocking palmitoylation of Wnt proteins. IWP-3 inhibits CK1γ3 and CK1ε only moderately and does not inhibit CK1α[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Wnt:40 nM (IC50) |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Molecular Formula | C22H17FN4O2S3 |
| Molecular Weight | 484.589 |
| Exact Mass | 484.049774 |
| PSA | 159.21000 |
| LogP | 5.30 |
| Index of Refraction | 1.776 |
| InChIKey | XVMHQSDMKWQNBK-UHFFFAOYSA-N |
| SMILES | Cc1ccc2nc(NC(=O)CSc3nc4c(c(=O)n3-c3ccc(F)cc3)SCC4)sc2c1 |
| Acetamide, 2-[[3-(4-fluorophenyl)-3,4,6,7-tetrahydro-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-N-(6-methyl-2-benzothiazolyl)- |
| 2-{[3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl}-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide |
| IWP-3 |