L-690,330

Modify Date: 2025-08-31 10:47:23

L-690,330 Structure
L-690,330 structure
Common Name L-690,330
CAS Number 142523-38-4 Molecular Weight 298.12400
Density 1.787g/cm3 Boiling Point 696.9ºC at 760mmHg
Molecular Formula C8H12O8P2 Melting Point N/A
MSDS N/A Flash Point 375.3ºC

 Use of L-690,330


L-690330 is a competitive inhibitor of inositol monophosphatase (IMPase) with a Kis of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively, exhibits 10-fold more sensitive than mouse and rat IMPase[1].

 Names

Name [1-(4-hydroxyphenoxy)-1-phosphonoethyl]phosphonic acid
Synonym More Synonyms

 L-690,330 Biological Activity

Description L-690330 is a competitive inhibitor of inositol monophosphatase (IMPase) with a Kis of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively, exhibits 10-fold more sensitive than mouse and rat IMPase[1].
Related Catalog
Target

Ki: 0.27 μM (Recombinant human IMPase), 0.19 μM (Recombinant bovine IMPase), 0.30 μM (Human frontal cortex IMPase), 0.42 μM (Bovine frontal cortex IMPase)[1]

References

[1]. Atack JR, et al. In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. J Neurochem. 1993 Feb;60(2):652-8.

 Chemical & Physical Properties

Density 1.787g/cm3
Boiling Point 696.9ºC at 760mmHg
Molecular Formula C8H12O8P2
Molecular Weight 298.12400
Flash Point 375.3ºC
Exact Mass 298.00100
PSA 164.14000
LogP 0.80010
Vapour Pressure 2.18E-20mmHg at 25°C
Index of Refraction 1.629
InChIKey JKOCAAWWDVHWKB-UHFFFAOYSA-N
SMILES CC(Oc1ccc(O)cc1)(P(=O)(O)O)P(=O)(O)O

 Synonyms

HMS3266J07
L-690,330
Amperozide hydrochloride
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