142523-38-4

142523-38-4 structure

Name: L-690,330
Chemical Name: [1-(4-hydroxyphenoxy)-1-phosphonoethyl]phosphonic acid
CAS Number: 142523-38-4
Molecular Formula: C₈H₁₂O₈P₂
Molecular Weight: 298.12400
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
Create Date: 2017-12-30 19:19:16
Modify Date: 2025-08-31 10:47:23
L-690330 is a competitive inhibitor of inositol monophosphatase (IMPase) with a Kis of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively, exhibits 10-fold more sensitive than mouse and rat IMPase[1].

Name	[1-(4-hydroxyphenoxy)-1-phosphonoethyl]phosphonic acid
Synonyms	HMS3266J07 L-690,330 Amperozide hydrochloride

Description	L-690330 is a competitive inhibitor of inositol monophosphatase (IMPase) with a Kis of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively, exhibits 10-fold more sensitive than mouse and rat IMPase[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Others
Target	Ki: 0.27 μM (Recombinant human IMPase), 0.19 μM (Recombinant bovine IMPase), 0.30 μM (Human frontal cortex IMPase), 0.42 μM (Bovine frontal cortex IMPase)[1]
References	[1]. Atack JR, et al. In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. J Neurochem. 1993 Feb;60(2):652-8.