PRI-724
Modify Date: 2025-09-17 11:38:30
PRI-724 structure
|
Common Name | PRI-724 | ||
|---|---|---|---|---|
| CAS Number | 1422253-38-0 | Molecular Weight | 658.64 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C33H35N6O7P | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PRI-724PRI-724 is a selective inhibitor of the CBP/β-catenin interaction. |
| Name | PRI-724 |
|---|
| Description | PRI-724 is a selective inhibitor of the CBP/β-catenin interaction. |
|---|---|
| Related Catalog | |
| Target |
CBP/β-catenin[1] |
| In Vivo | PRI-724 is phosphorylated-C-82 and is rapidly hydrolyzed to its active form C-82 in vivo. PRI-724 treatment reduces the fibrosis induced by CCl4 or BDL. C-82, an active form of PRI-724, inhibits the activation of isolated primary mouse quiescent hepatic stellate cells (HSCs) and promotes cell death in culture-activated HSCs[1]. |
| Animal Admin | Mice[1] Male wild-type (C57BL/6 and Balb/c) mice aged 8 to 11 weeks or 6 to 9 months are used. CCl4 administration or BDL induced liver fibrosis model is used for this study. The animals are intraperitoneally injected with or without 0.4 mg/mouse[1]. |
| References |
| Molecular Formula | C33H35N6O7P |
|---|---|
| Molecular Weight | 658.64 |
| InChIKey | VHOZWHQPEJGPCC-AZXNYEMZSA-N |
| SMILES | CC1C2N(C(=O)CN(C)N2C(=O)NCc2ccccc2)C(Cc2ccc(OP(=O)(O)O)cc2)C(=O)N1Cc1cccc2cccnc12 |