PRI-724

Names

[ CAS No. ]:
1422253-38-0

[ Name ]:
PRI-724

Biological Activity

[Description]:

PRI-724 is a selective inhibitor of the CBP/β-catenin interaction.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Stem Cell/Wnt >> Wnt

[Target]

CBP/β-catenin[1]

[In Vivo]

PRI-724 is phosphorylated-C-82 and is rapidly hydrolyzed to its active form C-82 in vivo. PRI-724 treatment reduces the fibrosis induced by CCl4 or BDL. C-82, an active form of PRI-724, inhibits the activation of isolated primary mouse quiescent hepatic stellate cells (HSCs) and promotes cell death in culture-activated HSCs[1].

[Animal admin]

Mice[1] Male wild-type (C57BL/6 and Balb/c) mice aged 8 to 11 weeks or 6 to 9 months are used. CCl4 administration or BDL induced liver fibrosis model is used for this study. The animals are intraperitoneally injected with or without 0.4 mg/mouse[1].

[References]

[1]. Osawa Y, et al. Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice. EBioMedicine. 2015 Oct 8;2(11):1751-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₃H₃₅N₆O₇P

[ Molecular Weight ]:
658.64

Related Compounds

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