1422253-38-0

1422253-38-0 structure

Name	PRI-724

Description	PRI-724 is a selective inhibitor of the CBP/β-catenin interaction.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> Wnt
Target	CBP/β-catenin[1]
In Vivo	PRI-724 is phosphorylated-C-82 and is rapidly hydrolyzed to its active form C-82 in vivo. PRI-724 treatment reduces the fibrosis induced by CCl4 or BDL. C-82, an active form of PRI-724, inhibits the activation of isolated primary mouse quiescent hepatic stellate cells (HSCs) and promotes cell death in culture-activated HSCs[1].
Animal Admin	Mice[1] Male wild-type (C57BL/6 and Balb/c) mice aged 8 to 11 weeks or 6 to 9 months are used. CCl4 administration or BDL induced liver fibrosis model is used for this study. The animals are intraperitoneally injected with or without 0.4 mg/mouse[1].
References	[1]. Osawa Y, et al. Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice. EBioMedicine. 2015 Oct 8;2(11):1751-8.

Molecular Formula	C₃₃H₃₅N₆O₇P
Molecular Weight	658.64