endo-BCN-PEG4-PFP ester

Modify Date: 2024-01-12 21:48:56

endo-BCN-PEG4-PFP ester Structure
endo-BCN-PEG4-PFP ester structure
Common Name endo-BCN-PEG4-PFP ester
CAS Number 1421932-52-6 Molecular Weight 607.563
Density 1.3±0.1 g/cm3 Boiling Point 650.9±55.0 °C at 760 mmHg
Molecular Formula C28H34F5NO8 Melting Point N/A
MSDS N/A Flash Point 347.5±31.5 °C

 Use of endo-BCN-PEG4-PFP ester


endo-BCN-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Pentafluorophenyl 1-(bicyclo[6.1.0]non-4-yn-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azanonadecan-19-oate
Synonym More Synonyms

 endo-BCN-PEG4-PFP ester Biological Activity

Description endo-BCN-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 650.9±55.0 °C at 760 mmHg
Molecular Formula C28H34F5NO8
Molecular Weight 607.563
Flash Point 347.5±31.5 °C
Exact Mass 607.220459
LogP 3.45
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.515

 Synonyms

Pentafluorophenyl 1-(bicyclo[6.1.0]non-4-yn-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azanonadecan-19-oate
2,7,10,13,16-Pentaoxa-4-azanonadecan-19-oic acid, 1-bicyclo[6.1.0]non-4-yn-9-yl-3-oxo-, 2,3,4,5,6-pentafluorophenyl ester