SiR-COOH

Modify Date: 2024-01-03 20:31:37

SiR-COOH Structure
SiR-COOH structure
Common Name SiR-COOH
CAS Number 1418275-26-9 Molecular Weight 472.61
Density N/A Boiling Point N/A
Molecular Formula C27H28N2O4Si Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SiR-COOH


SiR-COOH could be used to follow the intracellular location of the model therapeutic drug in GFP cells (Abs, 645 nm; Em, 676 nm)[1].

 Names

Name SiR-COOH

 SiR-COOH Biological Activity

Description SiR-COOH could be used to follow the intracellular location of the model therapeutic drug in GFP cells (Abs, 645 nm; Em, 676 nm)[1].
Related Catalog
In Vitro SiR-COOH could be used to conjugated inhibitors such as UNC2025 (Mer inhibitor). SiR-COOH is especially useful for small-molecule probes: it exhibits bright photostable fluorescence at near-infrared wavelengths, which are ideal for imaging deep through tissue; fluorescence is robust across physiological environments with little toxicity; it is amenable to super-resolution microscopy; and it exhibits an optimal degree of hydrophilicity for live-cell imaging[2].
References

[1]. Eunha Kim, et al. Red Si-rhodamine drug conjugates enable imaging in GFP cells. Chem Commun (Camb). 2014 May 4;50(34):4504-7.

[2]. Miles A Miller, et al. Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease. Chem Commun (Camb). 2017 Dec 19;54(1):42-45.https://pubmed.ncbi.nlm.nih.gov/29185561

 Chemical & Physical Properties

Molecular Formula C27H28N2O4Si
Molecular Weight 472.61
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