SiR-COOH

Modify Date: 2024-01-03 20:31:37

SiR-COOH structure	Common Name	SiR-COOH
	CAS Number	1418275-26-9	Molecular Weight	472.61
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₂₈N₂O₄Si	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SiR-COOH

SiR-COOH could be used to follow the intracellular location of the model therapeutic drug in GFP cells (Abs, 645 nm; Em, 676 nm)[1].

Name	SiR-COOH

Description	SiR-COOH could be used to follow the intracellular location of the model therapeutic drug in GFP cells (Abs, 645 nm; Em, 676 nm)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	SiR-COOH could be used to conjugated inhibitors such as UNC2025 (Mer inhibitor). SiR-COOH is especially useful for small-molecule probes: it exhibits bright photostable fluorescence at near-infrared wavelengths, which are ideal for imaging deep through tissue; fluorescence is robust across physiological environments with little toxicity; it is amenable to super-resolution microscopy; and it exhibits an optimal degree of hydrophilicity for live-cell imaging[2].
References	[1]. Eunha Kim, et al. Red Si-rhodamine drug conjugates enable imaging in GFP cells. Chem Commun (Camb). 2014 May 4;50(34):4504-7. [2]. Miles A Miller, et al. Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease. Chem Commun (Camb). 2017 Dec 19;54(1):42-45.https://pubmed.ncbi.nlm.nih.gov/29185561

Molecular Formula	C₂₇H₂₈N₂O₄Si
Molecular Weight	472.61

DC Chemicals Limited
China
Product Name: SiR-COOH
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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