α-HNJNAc

Modify Date: 2025-09-12 20:40:24

α-HNJNAc Structure
α-HNJNAc structure
 Common Name α-HNJNAc
CAS Number 1417906-42-3 Molecular Weight 234.25
Density N/A Boiling Point N/A
Molecular Formula C9H18N2O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of α-HNJNAc


α-HNJNAc is a potent, competitive hexosaminidases inhibitor without interfering with other glycosidases[1].

 Names

Name α-HNJNAc

 α-HNJNAc Biological Activity

Description α-HNJNAc is a potent, competitive hexosaminidases inhibitor without interfering with other glycosidases[1].
Related Catalog
In Vitro α-HNJNAc (10, 100µM) shows no effect on GM00737 and GM01426 cell lines, but some effect on GM02931 cell line with a significant 1.8 fold activity increase. a-HNJNAc (100µM; 3 days) has no toxicity on human HL60 cell proliferation[1]. NAGLU is inhibited more efficiently by a-HNJNAc (67 µM) than by the uncorrectly configured b-HNJNAc (374 µM)[1].
References

[1]. Sha Zhu, et al. Iminosugar C-Glycosides Work as Pharmacological Chaperones of NAGLU, a Glycosidase Involved in MPS IIIB Rare Disease. Chemistry. 2021 Aug 5;27(44):11291-11297.

 Chemical & Physical Properties

Molecular Formula C9H18N2O5
Molecular Weight 234.25
InChIKey GYKHMAHAJKZLAT-SYHAXYEDSA-N
SMILES CC(=O)NC1C(CO)NC(CO)C(O)C1O
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Chemsrc provides α-HNJNAc(CAS#:1417906-42-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of α-HNJNAc are included as well.>> amp version: α-HNJNAc

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