1417906-42-3

1417906-42-3 structure
1417906-42-3 structure
  • Name: α-HNJNAc
  • Chemical Name: α-HNJNAc
  • CAS Number: 1417906-42-3
  • Molecular Formula: C9H18N2O5
  • Molecular Weight: 234.25
  • Catalog: Research Areas Metabolic Disease
  • Create Date: 2022-04-08 00:37:37
  • Modify Date: 2025-09-12 20:40:24
  • α-HNJNAc is a potent, competitive hexosaminidases inhibitor without interfering with other glycosidases[1].

Name α-HNJNAc
Description α-HNJNAc is a potent, competitive hexosaminidases inhibitor without interfering with other glycosidases[1].
Related Catalog
In Vitro α-HNJNAc (10, 100µM) shows no effect on GM00737 and GM01426 cell lines, but some effect on GM02931 cell line with a significant 1.8 fold activity increase. a-HNJNAc (100µM; 3 days) has no toxicity on human HL60 cell proliferation[1]. NAGLU is inhibited more efficiently by a-HNJNAc (67 µM) than by the uncorrectly configured b-HNJNAc (374 µM)[1].
References

[1]. Sha Zhu, et al. Iminosugar C-Glycosides Work as Pharmacological Chaperones of NAGLU, a Glycosidase Involved in MPS IIIB Rare Disease. Chemistry. 2021 Aug 5;27(44):11291-11297.

Molecular Formula C9H18N2O5
Molecular Weight 234.25
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