α-HNJNAc

Names

[ CAS No. ]:
1417906-42-3

[ Name ]:
α-HNJNAc

Biological Activity

[Description]:

α-HNJNAc is a potent, competitive hexosaminidases inhibitor without interfering with other glycosidases[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vitro]

α-HNJNAc (10, 100µM) shows no effect on GM00737 and GM01426 cell lines, but some effect on GM02931 cell line with a significant 1.8 fold activity increase. a-HNJNAc (100µM; 3 days) has no toxicity on human HL60 cell proliferation[1]. NAGLU is inhibited more efficiently by a-HNJNAc (67 µM) than by the uncorrectly configured b-HNJNAc (374 µM)[1].

[References]

[1]. Sha Zhu, et al. Iminosugar C-Glycosides Work as Pharmacological Chaperones of NAGLU, a Glycosidase Involved in MPS IIIB Rare Disease. Chemistry. 2021 Aug 5;27(44):11291-11297.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₁₈N₂O₅

[ Molecular Weight ]:
234.25

Related Compounds

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