GLP-1(32-36)amide
Modify Date: 2025-08-25 18:33:58
GLP-1(32-36)amide structure
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Common Name | GLP-1(32-36)amide | ||
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| CAS Number | 1417302-71-6 | Molecular Weight | 570.73 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H50N10O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GLP-1(32-36)amideGLP-1(32-36)amide, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice[1][2]. |
| Name | GLP-1(32-36)amide |
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| Description | GLP-1(32-36)amide, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice[1][2]. |
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| Related Catalog | |
| In Vitro | GLP-1(32-36)amide (0.1-10 μM; 24 h) retains cell viability and decreases apoptosis against Streptozotocin (STZ; 1 μM) in INS‐1 cells[2]. Cell Viability Assay[2] Cell Line: INS‐1 cells Concentration: 0.1, 1, 10 μM Incubation Time: 24 hours Result: Decreased cell viability only approximately 30% in 0.1 μM and approximately 20% in ≥1 μM while approximately 45% in saline-treated controls. |
| In Vivo | GLP-1(32-36)amide (1 μmol/kg; i.p. once daily for 21 d) protects islet from damage, inhibits weight gain, and relieves symptoms of polydipsia in diabetic mice[2]. GLP-1(32-36)amide (1 μmol/kg; a single i.p.) slightly reduces the mean glucose lever at 30 min after the challenge of glucose in normal mice[2]. GLP-1(32-36)amide (50-70 nmol/kg/d; infusion for 12-16 weeks) prevents the development of diet-induced obesity and hepatic steatosis in high fat-fed mice[3]. Animal Model: Male KM mice (6-8 weeks; 18-22 g) injected with STZ[2] Dosage: 1 μmol/kg Administration: I.p. once daily for 21 days Result: Significantly lowered the cumulative values of food and water intake. Lowered fasting glucose. Reduced the level of Hemoglobin A1c (HbA1c). Improved glucose tolerance. Suppressed body weight gain. |
| References |
| Molecular Formula | C25H50N10O5 |
|---|---|
| Molecular Weight | 570.73 |
| InChIKey | VCMIHDDYZTYYJC-JPLJXNOCSA-N |
| SMILES | CC(C)CC(N)C(=O)NC(C(=O)NC(CCCCN)C(=O)NCC(=O)NC(CCCN=C(N)N)C(N)=O)C(C)C |