Bromo-PEG5-Boc

Modify Date: 2024-01-16 19:24:52

Bromo-PEG5-Boc Structure
Bromo-PEG5-Boc structure
Common Name Bromo-PEG5-Boc
CAS Number 1415800-38-2 Molecular Weight 429.344
Density 1.2±0.1 g/cm3 Boiling Point 453.9±40.0 °C at 760 mmHg
Molecular Formula C17H33BrO7 Melting Point N/A
MSDS N/A Flash Point 228.3±27.3 °C

 Use of Bromo-PEG5-Boc


Bromo-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Bromo-PEG5-t-butyl ester
Synonym More Synonyms

 Bromo-PEG5-Boc Biological Activity

Description Bromo-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 453.9±40.0 °C at 760 mmHg
Molecular Formula C17H33BrO7
Molecular Weight 429.344
Flash Point 228.3±27.3 °C
Exact Mass 428.140961
LogP 0.96
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.466

 Synonyms

MFCD22683304
2-Methyl-2-propanyl 1-bromo-3,6,9,12,15-pentaoxaoctadecan-18-oate
3,6,9,12,15-Pentaoxaoctadecan-18-oic acid, 1-bromo-, 1,1-dimethylethyl ester
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