albomycin

Modify Date: 2024-01-17 02:17:09

albomycin Structure
albomycin structure
Common Name albomycin
CAS Number 1414-39-7 Molecular Weight 1006.81000
Density N/A Boiling Point N/A
Molecular Formula C36H58FeN10O18S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of albomycin


Albomycin is an inhibitor of aminoacyl-tRNA synthetases with Trojan-horse effect. Albomycin is delivered by iron-chelator portion into bacterial through ferrichrome-specific transporter system. Albomycin combats against a wide range of Gram-positive and Gram-negative bacteria. Albomycin also serves as an efficient iron-scavenger of producer[1].

 Names

Name albomycin δ1
Synonym More Synonyms

 albomycin Biological Activity

Description Albomycin is an inhibitor of aminoacyl-tRNA synthetases with Trojan-horse effect. Albomycin is delivered by iron-chelator portion into bacterial through ferrichrome-specific transporter system. Albomycin combats against a wide range of Gram-positive and Gram-negative bacteria. Albomycin also serves as an efficient iron-scavenger of producer[1].
Related Catalog
In Vitro Albomycin 也与 FhuA 结合,与高铁色素竞争结合位点。FhuA 是埋在大肠杆菌外膜的 β 桶。或者,Albomycin 结合 FhuD,FhuD 是细胞膜 ABC 转运蛋白 FhuB/FhuC 的质周亚基[1]。 Albomycin 对肺炎链球菌的生长有明显的抑制作用,最低抑制浓度为 4-62 nM[1]。
References

[1]. Travin DY, et al. Natural Trojan horse inhibitors of aminoacyl-tRNA synthetases. RSC Chem Biol. 2021 Feb 22;2(2):468-485.  

 Chemical & Physical Properties

Molecular Formula C36H58FeN10O18S
Molecular Weight 1006.81000
Exact Mass 1006.30000
PSA 465.52000

 Synonyms

ferric 2-[[2-[[5-(acetyl-hydroxy-amino)-2-[[5-(acetyl-hydroxy-ami no)-2-[[5-(acetyl-hydroxy-amino)-2-amino-pentanoyl]amino]pentanoy l]amino]pentanoyl]amino]-3-hydroxy-propanoyl]amino]-3-[(2R,3S,4R, 5R)-3,4-dihydroxy-5-(3-methyl-2,4-dioxo
albomycin delta1
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