Nexturastat A
Modify Date: 2024-01-14 16:00:05
Nexturastat A structure
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Common Name | Nexturastat A | ||
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| CAS Number | 1403783-31-2 | Molecular Weight | 341.404 | |
| Density | 1.228±0.06 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C19H23N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Nexturastat ANexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM; no inhibition on other HDAC forms.IC50 value: 5 nM [1]Target: HDAC6 inhibitorNexturastat A displayed low micromolar activity compared to the low nanomolar activity against HDAC6. Moreover, it also demonstrated high levels of selective inhibition against members of the related Class 2 HDAC isozymes reaching >1000-fold selective in some cases. Compared to the pan-selective HDACI LBH589, Nexturastat A is approximately 100-fold less potent in inducing murine B16 melanoma cell death. |
| Name | 4-[[butyl(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide |
|---|---|
| Synonym | More Synonyms |
| Description | Nexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM; no inhibition on other HDAC forms.IC50 value: 5 nM [1]Target: HDAC6 inhibitorNexturastat A displayed low micromolar activity compared to the low nanomolar activity against HDAC6. Moreover, it also demonstrated high levels of selective inhibition against members of the related Class 2 HDAC isozymes reaching >1000-fold selective in some cases. Compared to the pan-selective HDACI LBH589, Nexturastat A is approximately 100-fold less potent in inducing murine B16 melanoma cell death. |
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| Related Catalog | |
| Target |
HDAC6:5.02 nM (IC50) HDAC8:0.954 μM (IC50) HDAC1:3.02 μM (IC50) HDAC7:4.46 μM (IC50) HDAC11:5.14 μM (IC50) HDAC3:6.68 μM (IC50) HDAC9:6.72 μM (IC50) HDAC2:6.92 μM (IC50) HDAC10:7.57 μM (IC50) HDAC4:9.39 μM (IC50) HDAC5:11.7 μM (IC50) |
| References |
| Density | 1.228±0.06 g/cm3 |
|---|---|
| Molecular Formula | C19H23N3O3 |
| Molecular Weight | 341.404 |
| Exact Mass | 341.173950 |
| PSA | 85.16000 |
| LogP | 2.37 |
| Appearance of Characters | white solid |
| Index of Refraction | 1.622 |
| Storage condition | -20℃ |
| Water Solubility | Very slightly soluble (0.13 g/L) (25 ºC) |
| Nexturastat-5mg |
| Nexturastat A |
| 4-{[Butyl(phenylcarbamoyl)amino]methyl}-N-hydroxybenzamide |
| Nexturastat-50mg |
| S7473 |
| Nexturastat-10mg |
| Benzamide, 4-[[butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxy- |
| Nexturastat-25mg |