1403783-31-2

1403783-31-2 structure

Name: Nexturastat A
Chemical Name: 4-[[butyl(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide
CAS Number: 1403783-31-2
Molecular Formula: C₁₉H₂₃N₃O₃
Molecular Weight: 341.404
Catalog: Biochemical Inhibitor Epigenetics HDAC inhibitor
Create Date: 2018-12-17 17:43:55
Modify Date: 2024-01-14 16:00:05
Nexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM; no inhibition on other HDAC forms.IC50 value: 5 nM [1]Target: HDAC6 inhibitorNexturastat A displayed low micromolar activity compared to the low nanomolar activity against HDAC6. Moreover, it also demonstrated high levels of selective inhibition against members of the related Class 2 HDAC isozymes reaching >1000-fold selective in some cases. Compared to the pan-selective HDACI LBH589, Nexturastat A is approximately 100-fold less potent in inducing murine B16 melanoma cell death.

Name	4-[[butyl(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide
Synonyms	Nexturastat-5mg Nexturastat A 4-{[Butyl(phenylcarbamoyl)amino]methyl}-N-hydroxybenzamide Nexturastat-50mg S7473 Nexturastat-10mg Benzamide, 4-[[butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxy- Nexturastat-25mg

Description	Nexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM; no inhibition on other HDAC forms.IC50 value: 5 nM [1]Target: HDAC6 inhibitorNexturastat A displayed low micromolar activity compared to the low nanomolar activity against HDAC6. Moreover, it also demonstrated high levels of selective inhibition against members of the related Class 2 HDAC isozymes reaching >1000-fold selective in some cases. Compared to the pan-selective HDACI LBH589, Nexturastat A is approximately 100-fold less potent in inducing murine B16 melanoma cell death.
Related Catalog	Research Areas >> Cancer
Target	HDAC6:5.02 nM (IC50) HDAC8:0.954 μM (IC50) HDAC1:3.02 μM (IC50) HDAC7:4.46 μM (IC50) HDAC11:5.14 μM (IC50) HDAC3:6.68 μM (IC50) HDAC9:6.72 μM (IC50) HDAC2:6.92 μM (IC50) HDAC10:7.57 μM (IC50) HDAC4:9.39 μM (IC50) HDAC5:11.7 μM (IC50)
References	[1]. Bergman JA, et al. Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. J Med Chem. 2012 Nov 26;55(22):9891-9.